Enactivism, action and normativity: a Wittgensteinian analysis

In this paper, we offer a criticism, inspired by Wittgenstein’s rule-following considerations, of the enactivist account of perception and action. We start by setting up a non-descriptivist naturalism regarding the mind and continue by defining enactivism and exploring its more attractive theoretical features. We then proceed to analyse its proposal to understand normativity non-socially. We argue that such a thesis is ultimately committed to the problematic idea that normative practices can be understood as private and factual. Finally, we offer a characterization of normativity as an essentially social phenomenon and apply our criticisms to other approaches that share commitments with enactivism

When my own beliefs are not first-personal enough

Richard Moran has defended the need for two modes of access to our mental contents, a first-personal and a third-personal one. In this paper we maintain that, in the moral case, an excess of concentration on the a third-personal perspective precludes accounting for our responsibility over our own beliefs and our capacity to normatively respond to the world.This paper has been partially funded by the MEC research project HUM2004-02330

Truth matters: normativity in thought and knowledge

A proposal to account for the objectivity of thought and language in terms of identity between facts, meanings and contents is offered. Furthermore, their normativity is related to their world involving character. Both proposals are jointly quietist: they avoid philosophical theorizing that explains thought in terms of world or viceversa

Is Testimonial Injustice Epistemic? Let Me Count the Ways

This work was funded by the Spanish Ministry of Economy (Project FFI2016-80088-P, FPI Predoctoral Fellow BES-2017-079933), the Spanish Ministry of Education, Culture, and Sports (FPU16/04185), the Spanish Ministry of Science (PID2019-109764RB-I00), Junta de Andalucia (B-HUM-459-UGR18), and the FiloLab Group of Excellence funded by the University of Granada.Miranda Fricker distinguishes two senses in which testimonial injustice is epistemic. In the primary sense, it is epistemic because it harms the victim as a giver of knowledge. In the secondary sense, it is epistemic, more narrowly, because it harms the victim as a possessor of knowledge. Her characterization of testimonial injustice has raised the following objection: testimonial injustice is not always an epistemic injustice, in the narrow, secondary sense, as it does not always entail that the victim is harmed as a knowledge-possessor. By adopting a perspective based on Robert Brandom’s normative expressivism, we respond to this objection by arguing that there is a close connection, conceptual and constitutive rather than merely causal, between the primary and the secondary epistemic harms of testimonial injustice, such that testimonial injustice always involves both kinds of epistemic harm. We do so by exploring the logic and functioning of belief and knowledge ascriptions in order to highlight three ways in which the secondary epistemic harm caused by testimonial injustice crystallizes: it undermines the epistemic agency of the victim, the epistemic friction necessary for knowledge, and the possibility of occupying particular epistemic nodes.Spanish Government FFI2016-80088-P BES-2017-079933 FPU16/04185 PID2019-109764RB-I00Junta de Andalucia B-HUM-459-UGR18FiloLab Group of Excellence - University of Granad

Twentieth-Century Paleoproteomics: Lessons from Venta Micena Fossils

Proteomics methods can identify amino acid sequences in fossil proteins, thus making it possible to determine the ascription or proximity of a fossil to other species. Before mass spectrometry was used to study fossil proteins, earlier studies used antibodies to recognize their sequences. Lowenstein and colleagues, at the University of San Francisco, pioneered the identification of fossil proteins with immunological methods. His group, together with Olivares’s group at the University of Granada, studied the immunological reactions of proteins from the controversial Orce skull fragment (VM-0), a 1.3-million-year-old fossil found at the Venta Micena site in Orce (Granada province, southern Spain) and initially assigned to a hominin. However, discrepancies regarding the morphological features of the internal face of the fossil raised doubts about this ascription. In this article, we review the immunological analysis of the proteins extracted from VM-0 and other Venta Micena fossils assigned to hominins and to other mammals, and explain how these methods helped to determine the species specificity of these fossils and resolve paleontological controversies.Plan Andaluz de Investigacion, Desarrollo e Innovacion, Groups CTS-564 CTS-20

Big Data and "New" Global History: Global Goods and Trade Networks in Early Modern China and Europe

GECEM Project (ERC-Starting Grant), ref. 679371, under the European Union's Horizon 2020 Research and Innovation Programme, www.gecem.eu.www.gecem.euhttps://www.gecem.eu/publications/index.htmlThis paper introduces an innovative method applied to global (economic) history using the tools of digital humanities through the design and development of the GECEM Project Database (www.gecem.eu; www.gecemdatabase.eu). This novel database goes beyond the static Excel files frequently used by conventional scholarship in early modern history studies to mine new historical data through a bottom-up process and analyse the global circulation of goods, consumer behaviour, and trade networks in early modern China and Europe. Macau and Marseille, as strategic entrepôts for the redistribution of goods, serve as the main case study. This research is framed within a polycentric approach to analyse the connectivity of south Chinese and European markets with trade zones of Spain, France, South America, and the Pacific.GECEM Project (ERC-Starting Grant), ref. 679371, Horizon 2020, project hosted at UP

Misinterpretation in microplastic detection in biological tissues: When 2D imaging is not enough

The presence of microplastics in the food chain is a public concern worldwide, and its analysis is an analytical challenge. In our research, we apply Raman imaging to study the presence of 1mum polystyrene microplastics in cryosections of Mytilus galloprovincialis due to its wide geographic distribution, widespread occurrence in the food web, and general high presence in the environment. Ingested microplastics are accumulated in the digestive tract, but a large number can also be rapidly eliminated. Some authors state that the translocation of microplastics to the epithelial cells is possible, increasing the risk of microplastics transmission along the food chain. However, as seen in our study, a surface imaging approach (2D) is probably not enough to confirm the internalization of particles and avoid misinterpretation. In fact, while some microplastic particles were detected in the epithelium by 2D Raman imaging, further 3D Raman imaging analysis demonstrated that those particles were dragged from the lumens to the epithelium during sample preparation due to the blade drag effect of the cryotome, and subsequently located on the surface of the analyzed cryosection, discarding the translocation to the epithelial cells. This effect can also happen when the samples are fortuitously contaminated during sample preparation. Several research articles that use similar analytical techniques have shown the presence of microplastics in different types of tissue. It is not our intention to put such results in doubt, but the present work points out the necessity of appropriate three-dimensional analytical methods including data interpretation and the need to go a step further than just surface imaging analysis.This work was funded by Basque Government (KK 2021/00001 ELKARTEK 2021/2022, IT1743-22); MINECO (PID 2020-118685RB-I00, PLASTeMER); further financial support by grant CEX2020-001038-M funded by MCIN/AEI/ 10.13039/50110001103

Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina.

nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes related to its metabolism are responsible for different retinal 76 dystrophies. cGMP-degrading phosphodiesterase 6 (PDE6) mutations cause around 4e5% of the retinitis 77 pigmentosa, a rare form of retinal degeneration. The aim of this study was to evaluate whether phar- 78 macological PDE6 inhibition induced retinal degeneration in cone-enriched cultures of porcine retina 79 similar to that found in murine models. PDE6 inhibition was induced in cone-enriched retinal explants 80 from pigs by Zaprinast. PDE6 inhibition induced cGMP accumulation and triggered retinal degeneration, 81 as determined by TUNEL assay. Western blot analysis and immunostaining indicated that degeneration 82 was accompanied by caspase-3, calpain-2 activation and poly (ADP-ribose) accumulation. Oxidative stress 83 markers, total antioxidant capacity, thiobarbituric acid reactive substances (TBARS) and nitric oxide 84 measurements revealed the presence of oxidative damage. Elevated TNF-alpha and IL-6, as determined by enzyme immunoassay, were also found in cone-enriched retinal explants treated with Zaprinast. Our 85 study suggests that this ex vivo model of retinal degeneration in porcine retina could be an alternative 86 model for therapeutic research into the mechanisms of photoreceptor death in cone-related diseases, 87 thus replacing or reducing animal experiments